There's a 53-foot, two-deck boat called the Annie on the Ohio River. Its owners are from Florence, Ala., and their plan is to go to Pittsburgh and back down again. I talked with them last week and got some photos. You can read the story here.
One thing they said that wasn't in the story is that they find the Ohio more interesting than the Tennessee. The Ohio, at least above the lower part of the river, has more people on it, meaning more towns and more places to visit. They like the friendly and helpful people they meet, of course.